Department of Physiology and Pharmacology
Center for Basic Sciences
The Autonomous University of Aguascalientes (UAA)
Inflammation of the nervous tissue, also referred to as neuroinflammation, may be triggered in response to a variety of cues, including infection, traumatic brain injury, toxic metabolites, or autoimmunity. Accumulating evidence suggests that neuroinflammation, which is characterized by infiltration of immune cells, activation of glial cells and production of inflammatory mediators in the peripheral and central nervous system, has an important role in the induction and maintenance of painful neuropathies leading to chronic neuropathic pain. Our lab is interested in the study of mechanisms underlying peripheral neuropathies that are originated particularly in response to toxic metabolites and infections. We are aso interested on the study of potential therapeutic targets involved in neuroimmune interactions, with special attention on the following research topics:
(i) Specific genes that are expressed in neuronal and glial subpopulations in pathological conditions.
(ii) Characterization of regulatory programs that drive phenotypic changes in nociceptive fibers.
(iii) regulation of axonal transport in sensory neurons.
(iv) Changes in transcription and translation in DRG neurons in response to viral-evoked neuropathies, metabolic diseases or chemotherapy-associated neuropathies.
(v) Sex-specific differences in pathological nociceptive processing.
Our long-term research goal is to identify the neuroimmune mechanisms that drive nociceptor plasticity with the aim to develop or repurpose drug candidates for inflammation and pain treatment.
Open positions for graduate students, come join us!
A peptide encoded within a 5' untranslated region promotes pain sensitization in mice. Barragan-Iglesias P, Kunder N, Wanghzou A, Black B, Ray PR, Lou TF, Bryan de la Peña J, Atmaramani R, Shukla T, Pancrazio JJ, Price TJ, Campbell ZT. Pain. 2021 Jan 11. doi: 10.1097/j.pain.0000000000002191. Online ahead of print.PMID: 33449506
Sex Differences in Nociceptor Translatomes Contribute to Divergent Prostaglandin Signaling in Male and Female Mice. Tavares-Ferreira D, Ray PR, Sankaranarayanan I, Mejia GL, Wangzhou A, Shiers S, Uttarkar R, Megat S, Barragan-Iglesias P, Dussor G, Akopian AN, Price TJ. Biol Psychiatry. 2020 Oct 5:S0006-3223(20)31952-1. doi: 10.1016/j.biopsych.2020.09.022. Online ahead of print.PMID: 33309016
Sex-dependent pronociceptive role of spinal α5 -GABAA receptor and its epigenetic regulation in neuropathic rodents. Franco-Enzástiga Ú, García G, Murbartián J, González-Barrios R, Salinas-Abarca AB, Sánchez-Hernández B, Tavares-Ferreira D, Herrera LA, Barragán-Iglesias P, Delgado-Lezama R, Price TJ, Granados-Soto V. J Neurochem. 2020 Aug 4. doi: 10.1111/jnc.15140. Online ahead of print.PMID: 32750173
Type I Interferons Act Directly on Nociceptors to Produce Pain Sensitization: Implications for Viral Infection-Induced Pain. Barragán-Iglesias P, Franco-Enzástiga Ú, Jeevakumar V, Shiers S, Wangzhou A, Granados-Soto V, Campbell ZT, Dussor G, Price TJ. J Neurosci. 2020 Apr 29;40(18):3517-3532. doi: 10.1523/JNEUROSCI.3055-19.2020. Epub 2020 Apr 3.PMID: 32245829
Pain Research Forum (PRF) is an interactive web community dedicated to finding new treatments for pain conditions. Modeled on the highly successful Alzheimer Research Forum and similar sites for schizophrenia and Parkinson’s disease, the PRF aims to build a virtual meeting place for investigators in academia, industry, medicine and other fields who are working to translate basic neurobiology into new treatments for chronic pain.
The International Association for the Study of Pain (IASP) works to support research, education, clinical treatment, and better patient outcomes for all pain conditions with the goal of improving pain relief worldwide.
With more than 7,000 members representing 125 countries, 96 national chapters, and 24 Special Interest Groups (SIGs), IASP fosters the exchange of ideas and education to advance the field of pain science. Membership is open to all professionals involved in research, diagnosis, or treatment of pain.
Founded in 1973, the association is governed by an international Council composed of officers and councilors elected by the membership. Members may also serve on committees, task forces, and working groups. The current IASP president is Claudia Sommer, MD, Professor of Neurology, Department of Neurology, University of Würzburg, Germany.
The Allen Institute for Brain Science uses a unique approach to generate data, tools and knowledge for researchers to explore the biological complexity of the mammalian brain. This portal provides access to high quality data and web-based applications created for the benefit of the global research community.